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Side by side

Compound comparison

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Fisetin

OTC · Grade C

Goals
longevity
Evidence
1 RCT / 5 animal / 4 in vitro
Routes
oral
WADA
No
FDA
Not approved
Cancer caution
none
Typical dose
—
Half-life
(4) Rapidly cleared from plasma with a short half-life (~1-2 hours in rats)
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
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Dasatinib + Quercetin

Off-label · Grade C

Goals
healing, longevity, immune
Evidence
0 RCT / 0 animal / 0 in vitro
Routes
oral
WADA
No
FDA
Not approved
Cancer caution
caution
Typical dose
—
Half-life
Half-life: 3-5 hours
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
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J-147

Research chemical · Grade C

Goals
cognition, longevity, mitochondria
Evidence
1 RCT / 5 animal / 4 in vitro
Routes
oral
WADA
S4
FDA
Not approved
Cancer caution
caution
Typical dose
—
Half-life
—
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
View full report →

Metformin

FDA-approved · Grade C

Goals
longevity, weight-loss, mitochondria, gut
Evidence
10 RCT / 4 animal / 3 in vitro
Routes
oral
WADA
No
FDA
Approved
Cancer caution
none
Typical dose
—
Half-life
—
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
View full report →