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Compound comparison

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Kisspeptin-10

Research chemical · Grade C

Goals
hormonal, libido
Evidence
5 RCT / 3 animal / 2 in vitro
Routes
injectable-sc
WADA
No
FDA
Not approved
Cancer caution
none
Typical dose
—
Half-life
longest half-life (~28 minutes IV)
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
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Gonadorelin

FDA-approved · Grade C

Goals
hormonal, libido
Evidence
—
Routes
injectable-sc
WADA
No
FDA
Approved
Cancer caution
none
Typical dose
—
Half-life
The 2-4 minute plasma half-life means that any gonadorelin injection is a brief pulse that clears within minutes
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
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Enclomiphene

Off-label · Grade C

Goals
hormonal, libido, muscle
Evidence
4 RCT / 1 animal / 2 in vitro
Routes
oral
WADA
S4
FDA
Not approved
Cancer caution
none
Typical dose
—
Half-life
short plasma half-life (estimated ~10-12 hours in humans under repeated dosing)
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
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Human Chorionic Gonadotropin

FDA-approved · Grade B

Goals
hormonal, libido, muscle
Evidence
14 RCT / 0 animal / 0 in vitro
Routes
injectable-sc, injectable-im
WADA
S2
FDA
Approved
Cancer caution
hard-stop
Typical dose
—
Half-life
The 36-hour half-life of hCG vs LH's 30 minutes reflects the CTP extension's protective effect against renal clearance and plasma peptidase degradation
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
View full report →