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Compound comparison

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Metformin

FDA-approved · Grade C

Goals
longevity, weight-loss, mitochondria, gut
Evidence
10 RCT / 4 animal / 3 in vitro
Routes
oral
WADA
No
FDA
Approved
Cancer caution
none
Typical dose
Half-life
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
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MOTS-c

Research chemical · Grade C

Goals
mitochondria, longevity, weight-loss, muscle
Evidence
0 RCT / 12 animal / 0 in vitro
Routes
injectable-sc
WADA
S4
FDA
Not approved
Cancer caution
caution
Typical dose
Half-life
Plasma half-life is estimated at approximately 30-60 minutes in animal models, but human clearance has not been measured
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
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5-Amino-1MQ

Research chemical · Grade C

Goals
muscle, weight-loss, mitochondria
Evidence
0 RCT / 4 animal / 3 in vitro
Routes
oral
WADA
No
FDA
Not approved
Cancer caution
caution
Typical dose
Half-life
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
View full report →

ATX-304

Research chemical · Grade C

Goals
weight-loss, mitochondria
Evidence
1 RCT / 6 animal / 3 in vitro
Routes
oral
WADA
No
FDA
Not approved
Cancer caution
caution
Typical dose
Half-life
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
View full report →