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Compound comparison

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MIF-1 (Pro-Leu-Gly-NH₂)

Research chemical · Grade C

Goals
cognition, sleep
Evidence
0 RCT / 4 animal / 2 in vitro
Routes
injectable-sc, nasal, oral
WADA
No
FDA
Not approved
Cancer caution
none
Typical dose
Half-life
The dosing frequency for MIF-1 based on this half-life would theoretically be very low — perhaps once every 2-5 days rather than daily
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
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Pinealon

Bioregulator · Grade C

Goals
cognition, sleep, longevity
Evidence
0 RCT / 1 animal / 2 in vitro
Routes
injectable-sc, injectable-im
WADA
No
FDA
Not approved
Cancer caution
caution
Typical dose
Community protocols commonly cite 2 mg daily for 10 days; evidence is extrapolated
Half-life
Unknown in humans; short peptide, likely rapid systemic clearance
Primary mechanism
Direct chromatin-interaction hypothesis
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DSIP

Research chemical · Grade C

Goals
cognition, sleep
Evidence
1 RCT / 6 animal / 1 in vitro
Routes
injectable-sc, nasal
WADA
No
FDA
Not approved
Cancer caution
none
Typical dose
Half-life
In animal studies: the half-life appears even shorter — approximately 4-5 minutes in vivo
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
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Epitalon

Bioregulator · Grade C

Goals
cognition, sleep, longevity
Evidence
0 RCT / 5 animal / 3 in vitro
Routes
injectable-sc, nasal
WADA
No
FDA
Not approved
Cancer caution
hard-stop
Typical dose
Half-life
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
View full report →