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Compound comparison

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Setmelanotide (Imcivree)

FDA-approved · Grade C

Goals
weight-loss
Evidence
3 RCT / 3 animal / 2 in vitro
Routes
injectable-sc
WADA
No
FDA
Approved
Cancer caution
none
Typical dose
—
Half-life
—
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
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Melanotan II (MT-II)

Research chemical · Grade C

Goals
beauty, libido, weight-loss
Evidence
2 RCT / 0 animal / 0 in vitro
Routes
injectable-sc, nasal
WADA
S4
FDA
Not approved
Cancer caution
caution
Typical dose
—
Half-life
—
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
View full report →

Melanotan 1

FDA-approved · Grade C

Goals
beauty, immune
Evidence
5 RCT / 2 animal / 2 in vitro
Routes
injectable-sc
WADA
No
FDA
Approved
Cancer caution
none
Typical dose
—
Half-life
The free-injection form (research chemical, SubQ): plasma half-life approximately 33 minutes from the rapid absorption and distribution phase (Dorr et al., 1996 — the Arizona cl…
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
View full report →

5-Amino-1MQ

Research chemical · Grade C

Goals
muscle, weight-loss, mitochondria
Evidence
0 RCT / 4 animal / 3 in vitro
Routes
oral
WADA
No
FDA
Not approved
Cancer caution
caution
Typical dose
—
Half-life
—
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
View full report →