Immune & Thymic

The ITP Mouse Data: Lifespan Extended at Multiple Labs, Doses, and Start Ages. The PEARL Trial (April 2025): First 48-Week Placebo-Controlled Human Longevity Trial Published. The Bioavailability Finding That Changes Everything: Compounded Rapamycin Is ~3x Less Bioavailable Than Commercial. Intermittent vs Continuous Dosing: The Pharmacological Divide Between Transplant Medicine and Longevity Use. The Immunosuppression Risk That Needs Honest Framing. The Drug Interaction Profile That Makes This one of the highest-interaction-risk compounds in this reference set to Stack. Why the Community Uses ~6 mg Weekly. What Happens When You Stop.

Alpha-MSH's Anti-Inflammatory Fragment — And It May Work Completely Differently Than Everyone Thinks

The Only Senolytic With Real Human Trial Data. Tested at the Mayo Clinic. Proven to Clear Senescent Cells in Humans. Dasatinib Is a Chemotherapy Drug. The Community Is Using It Without Prescriptions, ECGs, or Drug Interaction Screens.

A 2017 Paper Showed It Extended Mouse Lifespan by 24.8%. The Community Is Already Injecting It. There Has Never Been a Human Safety Trial. And It Works by Interfering With p53.

Scope appropriateness is the question: local gut peptides are being stacked for barrier integrity and inflammatory signaling, not for systemic regeneration claims.

Four Organ-Specific Bioregulators from the Russian Khavinson Research Tradition. The Theory That Short Peptides Regulate Gene Expression in a Tissue-Specific Way. Cortexin: A Russian-Approved Neuroprotective Extract with Multi-Receptor Activity. CardioCytogen (Ala-Glu-Asp-Arg): The Cardiac Fibroblast Modulator. Crystagen: Connective Tissue and Cartilage Bioregulator. Bronchogen: Pulmonary Bioregulator Tetrapeptide. The Shared Evidence Architecture That Applies to All Four.

40+ Years of Russian Research. 500+ Publications. One Institution. The Most Concentrated Single-Lab Provenance of Any Compound Class in this reference. Vladimir Khavinson (1946-2024) and the St. Petersburg Institute of Bioregulation and Gerontology. The Epigenetic Chromatin Mechanism. The Cytomax vs Cytogen Distinction. The 6-to-8-Year Mortality Study. The 2025 Independent Replication That Changed the Evidence Conversation. 14 Organ-Specific Bioregulators — Their Sequences, Targets, Evidence, and Protocols.

Adds KPV’s local gut anti-inflammatory signal to the GLOW recovery-and-skin stack.

Every Cell Makes It. Every Major Disease Depletes It. Oral Supplementation Below 1% Bioavailability in Standard Form. IV Delivery With Documented Fatalities. A Billion-Dollar Skin Whitening Industry Built on Mixed Evidence. The Precursor Strategy That Outperforms the Molecule Itself.

The Only Human Cathelicidin. Antimicrobial, Anti-Biofilm, Pro-Angiogenic, Immunomodulatory, Wound-Healing. Phase IIb Clinical Evidence in Chronic Wounds. Overexpressed in Rosacea, Ovarian Cancer, Breast Cancer, Lung Cancer, Melanoma. Tumor-Suppressive in Colon and Gastric Cancer. The Most Contextually Bidirectional Compound in this reference. Vitamin D Is Its Most Important Natural Inducer.

FDA-Approved. EMA-Approved. The First Effective Treatment for a Disease That Traps Patients Indoors. The Compound That Tans Without UV. The Nevi Darkening Warning the Community Ignores. The Melanoma Question That Has No Clean Answer. The Widest Gap in this reference Between the Disease It Was Made For and the Use It Is Actually Known For.

The Drug That Was Going to Treat Leaky Gut and Celiac Disease — And How the Phase 3 Trial Ended. What Zonulin Actually Is and Why Tight Junction Regulation Is Hard to Measure. Four Phase 2 RCTs: Symptom Improvement With Gluten Challenge. The Phase 3 Discontinuation in 2022. The N-Acetyl Modification That Limitless Sells: What It Adds and What It Doesn’t Change. How This Differs From BPC-157 and KPV in the Gut Stack.

Tuftsin → Selank → N-Acetyl Selank Amidate: Three Generations of Molecular Engineering. Russian-Approved Anxiolytic Without Sedation, Without Tolerance, Without Dependence. Comparable to Benzodiazepines for GAD With Psychostimulant Properties They Lack. BDNF Upregulation. Enkephalin Stabilization. The Evidence Is for Selank. NASA Is the More Stable Delivery Format Whose Equivalent Efficacy Is Chemically Logical but Clinically Unproven.

FDA-Approved at 50 mg for Opioid and Alcohol Use Disorder Since 1984. Off-Label at 1.5-4.5 mg (LDN) — Two Completely Different Mechanisms at Two Completely Different Doses. TLR4 Blockade on Microglia. The Endorphin Rebound. A Lancet Rheumatology RCT in 2024. An Evidence Base Growing Faster Than Pharma Has Any Reason to Fund. The Most Favorably Tolerated Prescription Drug in Its Evidence Literature.

Cancer-Selective Membrane Pore Formation. MDM2 on the Surface of Cancer Cells as the Target. No Phase 1 Human Trials. No FDA Review. No Human Safety Data. Used by Cancer Patients as Last Resort. The Most Ethically Complex Chapter in this reference. What the Evidence Actually Shows. What It Cannot Show. Why Active Cancer Patients Must Read This Chapter Before Any Self-Administration Decision.

The Compound Designed to Kill Cancer Cells by Forming Pores in Their Membranes. The Reversal: Active Malignancy Is the Designed Use Context. How MDM2 on Cancer Cell Surfaces Creates the Selectivity Mechanism. p53 AA17-26 + Penetratin: What Each Domain Does. PNC-27 vs PNC-28: The Structural Difference and Whether It Matters. In Vitro Human Cancer Cell Data and In Vivo Mouse Model Evidence. The Community Off-Label Use Question.

Russia Approved It. The West Has Never Independently Validated It. And It Might Be the Only Anxiolytic That Doesn't Make You Stupid.

Approved in 37+ Countries. The Most Extensively Studied Thymic Peptide in Clinical Medicine. 30+ RCTs. 11,000+ Subjects. HBeAg Seroconversion RR 2.31. A Positive Sepsis Trial in 2013 Followed by a Definitive Negative Phase 3 in 2025. The US Regulatory Rollercoaster: Category 2 (2023) → Nomination Withdrawn (2024) → Pending PCAC Review (2026). Immunomodulator, Not Immunostimulant — A Critical Distinction.

The Only Thymic Hormone That Requires a Metal Cofactor. Biologically Inactive Without Zinc. The Most Important Clinical Point: Zinc Deficiency Causes Functional Thymulin Deficiency — And Zinc Supplementation Restores It. One Human Interventional Study from 1982. Extensive Animal Evidence. The Chapter That Is Also a Zinc Education.

Full 28-amino-acid thymosin alpha-1 with an appended RGDR tumor-targeting sequence. The RGDR motif binds integrin αvβ3 overexpressed on tumor vasculature, creating a China-based research construct designed to concentrate TA1 immune activation at tumor sites.

The Most Physiologically Broad Compound in this reference. 28 Amino Acids. Every System in the Body. VPAC1 and VPAC2. The 90-Second Half-Life Problem That Blocked IV Use. How Intranasal Administration Changed Everything. Dr. Shoemaker's CIRS Protocol: 300+ Physicians, 90%+ Symptom Reduction. The Long-COVID Connection. Aviptadil COVID ARDS Trials. The Mast Cell / MCAS Intersection. Why the Community Uses It and What the Evidence Actually Shows.