Selank
Research chemical · Grade C
Goals
cognition, sleep, immune
Evidence
3 RCT / 1 animal / 0 in vitro
Typical dose
Intranasal: 250-500 mcg per session (2-5 drops or sprays), 1-2x daily. SubQ: 150-250 mcg daily. Cycles of 10-14 days with breaks standard in Russian protocol; community often runs longer.
Half-life
~2-5 minutes in plasma. Effects last hours per dose via downstream signaling. Rapid peptidase degradation makes oral bioavailability negligible.
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
Naltrexone / LDN
FDA-approved · Grade C
Goals
healing, cognition, sleep, gut, immune
Evidence
4 RCT / 3 animal / 2 in vitro
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.
Semax
Research chemical · Grade C
Evidence
3 RCT / 6 animal / 2 in vitro
Typical dose
Nootropic: 250-1,200 mcg/day intranasally, split AM/midday. N-Acetyl Semax: 30-40% lower dose, once daily. Stroke (Russian clinical): 9,000-18,000 mcg/day — clinical setting only.
Half-life
Semax has a plasma half-life of approximately 20-30 minutes — longer than Selank's 2-5 minutes due to the Pro-Gly-Pro extension's greater resistance to peptidase degradation
Primary mechanism
Mechanism diagram showing the compound's primary signaling pathway and downstream effects.